2020 Guangdong Science and Technology Award Publicity Form

2020 Guangdong Science and Technology Award Publicity Form

According to the relevant requirements for the nomination and application of the 2020 Guangdong Science and Technology Award, our company’s participation in the application for the 2020 Guangdong Science and Technology Award project “the establishment and application of the key diagnosis and treatment technology system for infectious endophthalmitis” is now publicized. The publicity period is from July 29, 2020 to August 4, 2020. Any unit or individual who has any objection to participating in the declared project can submit it to our administrative personnel department in written form before 17:30 pm on August 4, 2020. The objection shall be signed by the real name or affixed with the official seal of the unit, and the contact information shall be indicated. Late objections will not be accepted.

Contact: Miss Chen

Contact number: 020-28687088

Attachment: publicity content

Guangzhou Vesber Biological Technology Co., Ltd.

July 29, 2020

Announcement content: 2020 Guangdong Science and Technology Award announcement form, project introduction


July | Vesber’s Best RIO Paper Recommendation

R —— Retina Recommendation
Purpose:To identify factors associated with persistent subretinal fluid (SRF) after small-gauge pars plana vitrectomy for primary rhegmatogenous retinal detachment.
Methods:This retrospective study included patients from 2 tertiary centers who
underwent pars plana vitrectomy for repair of rhegmatogenous retinal detachment between2013 and 2016. Preoperative and intraoperative parameters were examined for associationwith development of SRF.
Results:Overall, 153 eyes of 153 patients, mean age of 55.2 ± 17.9 years were included. Persistent SRF occurred in 15.0% (n = 23) and was associated with high myopia (65.22 vs. 26.15%, P , 0.001), macula-involving retinal detachment (91.30 vs. 66.15%, P = 0.02), phakic lens status (86.96 vs. 66.15%, P = 0.04), and younger age (47.8 ± 18.7 vs. 56.5 ± 17.5, P = 0.04) while drainage retinotomy was protective (13.04 vs. 34.11%, P = 0.04). In multivariate analysis, high myopia (P = 0.009) and macula-involving retinal detachment (P = 0.004) were associated with SRF, while drainage retinotomy was protective (P = 0.03). Persistent SRF was associated with outer retinal band irregularity (30.4 vs. 9.3%, P = 0.005). There were no significant differences in terms of change in best-corrected visual acuity from presentation (P = 0.70), or final best-corrected visual acuity (P = 0.54).
Conclusion:Eyes with preoperative high myopia and macular involvement, and those inwhich a drainage retinotomy was not performed, were more likely to develop persistent SRF.
Recommended reason:
This article discusses factors related to determining persistent subretinal fluid (SRF) in patients with primary rhegmatogenous retinal detachment treated with minimally invasive vitrectomy. The results showed that persistent SRF was associated with high myopia. In multivariate analysis, high myopia and retinal detachment involving the macula were associated with SRF. The special feature of the article is that the author innovatively refers to a number of different ophthalmological diseases, compares the correlation between different diseases and SFR, and uses mathematical statistics to obtain preoperative high myopia and macular involvement eyes and undrained retina Incision eye is closely related to SFR, that is, high myopia, lens state and low age are not related. This article has certain limitations. On the one hand, the main age of the sample sampling is 55.2±17.9 years old, and there is no control in the low-age group; on the other hand, the study time is only three years from 2013 to 2016, which requires longer observation time and frequency data to support. In addition, the influence of variables in this article on the condition of the contralateral eye was not included in the study.
I —— Investigative Ophthalmology & Visual Science Recommendation
Increased Glial Fibrillary Acid Protein and Vimentin in Vitreous Fluid as a Biomarker for Proliferative Vitreoretinopathy
Purpose:Glial fibrillary acid protein (GFAP) and vimentin are type III intermediate filament proteins, ubiquitously expressed in retinal glial cells. Under retinal stress, both GFAP and vimentin are well-known sensitive markers for retinal gliosis. However, little is known about whether these proteins are released into the vitreous body in response to retinal gliosis or are related to the severity of retinal gliosis seen in proliferative vitreoretinopathy (PVR).
Methods:Vitreous fluids were collected from 44 patients who underwent pars plana vitrectomy for macular hole (Group 1; n = 8), epiretinal membrane (Group 2; n = 8), or retinal detachment (RD) with various degrees of PVR (Group 3; n = 28). The severity of PVR was determined by cumulative scores using PVR classification. GFAP, vimentin, and total protein levels from the vitreous samples were measured.
Results:Both GFAP and vimentin levels were significantly elevated in vitreous fluid from Group 3 (RD) compared with Groups 1 and 2 (P < 0.01). GFAP levels (ng/mL) were 12.4± 9.8, 17.5 ± 17.7, and 572.0 ± 11659.7, and vimentin levels (ng/mL) were 40.8 ± 61.9, 88.6 ± 86.8, and 3952.8 ± 8179.5 in Groups 1, 2, and 3, respectively. Total protein levels were not significantly different among the three groups. Elevated GFAP and vimentin levels in Group 3 were positively correlated with the areas of RD (P < 0.01, r = 0.53 in GFAP and P < 0.05, r = 0.46 in vimentin) and PVR scores (P < 0.05, r = 0.46 in GFAP and P < 0.00001, r = 0.76 in vimentin).
Conclusion:Our data suggest that human vitreous GFAP and vimentin are protein biomarkers for PVR, and reactive gliosis may play a part in PVR formation.
Recommended reason:
In this study, the macular hole (group 1), macular epiretinal membrane (group 2), and retinal detachment (RD) with different degrees of PVR (group 3) were compared in three groups of patients receiving PPV in vitreous fibrillary acidic protein (group 3). GFAP), vimentin and total protein levels, and the relationship between the three protein levels and RD area and PVR score. The results showed that there was no significant difference in total protein levels among the three groups. The levels of GFAP and vimentin in group 3 were significantly higher than those in the other two groups, and they were positively correlated with RD area and PVR score. This study is the first to prove that the increase in vitreous GFAP and vimentin is related to the severity of PVR. In the absence of treatment for PVR, early identification and prevention of PVR formation are important to prevent further vision loss. The study showed that the increased levels of GFAP and vimentin in the vitreous after RD may be a sign of the formation of PVR, and patients in this case need more active treatment and prevention. The limitation of this study is that the number of patients is small, and the vitreous GFAP and vimentin lack normal physiological value. The cross-sectional design of the eye restricts researchers to further analyze the source of these proteins or the causal relationship between these proteins in retinal detachment and PVR. The role of GFAP and vimentin in the formation of PVR needs to be further studied in the future.
O —— Ophthalmology Recommendation
Myopia and Childhood Migration:A Study of 607 862 Adolescents
Purpose:Immigration studies can shed light on myopia development and reveal high-risk populations. To this end, we investigated the association among immigration, age at immigration, and myopia occurrence during adolescence.
Design:Population-based, retrospective, cross-sectional study.
Participants:Six hundred seven thousand eight hundred sixty-two adolescents, Israeli born and immigrants, with origins in the former Union of Soviet Socialist Republics (USSR), Ethiopia, or Israel, assessed for medical fifitness for mandatory military service at 17 years of age between 1993 and 2016.
Methods:Myopia and high myopia were defined based on right eye refractive data. Age at immigration was categorized into 0 to 5 years of age, 6 to 11 years of age, and 12 to 19 years of age. Univariate and multivariate logistic regression models were created. Myopia odds ratios (ORs) were calculated according to immigration status, with Israeli-born natives as controls. Next, myopia ORs were calculated according to age at immigration, with Israeli-born of same origin as controls. Main Outcome Measures: Myopia prevalence and ORs.
Results:Myopia was less prevalent among immigrants than Israeli-born controls. When stratifified according to age at immigration, a decrease in myopia prevalence and ORs with increasing age at migration were observed, most prominent in immigrants arriving after 11 years of age, who also showed lower high-myopia ORs. The immigrants from the USSR and Ethiopia arriving after 11 years of age showed a myopia OR of 0.65 (95% con- fifidence interval [CI], 0.63e0.67; P < 10e205) and 0.52 (95% CI, 0.46e0.58; P < 10e27) compared with the Israeliborn controls. Notably, Ethiopians arriving earlier than 5 years of age showed a 2-fold higher myopia OR than those migrating after 11 years of age.
Conclusion:Immigrants arriving after 11 years of age showed markedly lower ORs for myopia and high myopia relative to Israeli-born controls or those arriving during early childhood, likely because of environmental and lifestyle changes. Differences between immigrants arriving up to 5 years of age and those arriving between 6 and 11 years of age were relatively smaller, suggesting exposures at elementary school age play a greater role in this population.
Recommended reason:
Adolescents’ vision health is related to the future of the motherland. Under the background of the contemporary computer age, understanding the factors of adolescents’ myopia is very important to protect their vision. Based on the selection of a large number of 17-year-old young people’s physical examination data, the article compares the incidence of myopia among young people and the age of immigration. It is concluded that the incidence of myopia is relatively low among the children of native Israel, while the incidence of myopia is relatively low for children who are immigrants after the age of 11. It implies that the relative exposure factors of the local primary school age in Israel are related to the increase of myopia rate. The article adopts sufficient sample size and reliable data. Through the establishment of multiple comparisons, it is determined that the indirect impact of changes in the living environment on vision is unquestionable, suggesting that we are concerned about the impact of environmental changes on young people, especially the continuous changes in the multimedia age, even if we are in the same environment, we must also pay attention The environment of many years ago and the contemporary environment have an impact on the vision of young people. The limitation of the article is that the article only has eye diopter data and immigration age data, and there is no design for related environmental factors, educational factors, and social factors. In the future, further cause analysis can be considered for this point.
The original texts of the three papers have been placed on the Baidu network disk, click on the “link”, enter the extraction code: bp9j, you can download the paper.

China Eye Valley·Central Incubation Park opened, and a subsidiary of Guangzhou Vesber settled in

China Eye Valley·Central Incubation Park opened, and a subsidiary of Guangzhou Vesber settled in

July 1, China eye · Central Valley Incubator officially opened. Chinese Eye valley – the focus of the whole industry chain of eye health Branch Park rapid rise in a “dragon culture” Legend of the Wenzhou area, the country is becoming a new landmark in the field of life and health.

Chen Weijun, Member of the Standing Committee of the Zhejiang Provincial Party Committee and Secretary of the Wenzhou Municipal Party Committee, Gaoyuan Yao, Deputy Secretary of the Wenzhou Municipal Party Committee and Mayor, Wang Jun, Member of the Standing Committee and Secretary-General of the Wenzhou Municipal Party Committee, Wang Chi, Vice Mayor of Wenzhou Municipal People’s Government, Tang Xiaoshu, Vice Mayor of Wenzhou Municipal People’s Government and other leaders Attended this opening ceremony.

Focus on eye health and create a new height for the life and health industry

China Eye Valley was jointly built by Wenzhou Longwan District (High-tech Zone) and the Eye Optometry Hospital affiliated to Wenzhou Medical University, and the construction was officially launched in September 2018. Relying on the advantages of Wenzhou Medical University and the Eye Optometry Hospital affiliated to Wenzhou Medical University in terms of brand, resources, talents, scientific research, etc., the park strives to build a world-class eye health care center jointly participated by the government, medical institutions, investment institutions, and eye health companies. An industrial chain complex, this is also the only whole-industry chain science and technology park in the national and even global eye health field.

Focusing on the core concept of eye health, China Eye Valley currently has a planned area of ​​1,000 acres. It focuses on promoting projects such as the Central Park Incubation Park and Science and Technology Park, and comprehensively builds a world-class vision technology research and development system, a world-class vision technology academic exchange platform, A world-class high-end medical center for vision, a world-class gathering area for innovative and entrepreneurial talents in vision, and a world-class incubator for vision and high-tech industries. The goal is to become a top national and world-class innovation center for the eye health industry. Up to now, China Eye Valley has completed a fixed asset investment of 536 million yuan.


Many well-known companies settled in, including Guangzhou Satellite Vesber subsidiary

At the opening ceremony, China Eye Valley ushered in a new batch of settled companies, and at the same time held the signing ceremony of the Eye Health Innovation Leading Fund. At present, the incubator has attracted 41 enterprises in related fields at home and abroad to settle down, including the world’s top 500 companies Alcon, the national high-tech enterprise Guangzhou Vesber Biological Technology Co., Ltd. subsidiary-Wenzhou Meiyi Biological Technology Co., Ltd. Many well-known companies.

Guangzhou Vesber Biological Technology Co., Ltd. is a national high-tech enterprise focusing on the R&D, production and sales of high-end ophthalmic innovative products. It is located in the Guangdong Medical Valley Industrial Park, the core area of ​​the Guangdong-Hong Kong-Macao Greater Bay Area. The company covers an area of ​​5,000 square meters. Its representative products are The world’s original foldable artificial vitreous balloon, perispheric pressure balloon and high myopia posterior scleral reinforcement device. The subsidiary of Guangzhou Satellite TV Bo-Wenzhou Meiyi Biological Technology Co., Ltd. is mainly engaged in the research and development of post-scleral reinforcement devices for high myopia, providing new technical treatment for patients with high myopia macular split.

In addition, the post-scleral reinforcement device for high myopia won the Excellence Award in the 2019 China Eye Valley-Innovation and Entrepreneurship Global Challenge Finals. Currently, posterior scleral reinforcement is the only surgical method that can alleviate the development of high myopia. However, the current posterior scleral reinforcement surgery has not formed a commercial product. The main reasons are the following two points: First, the reinforcement material is generally allogeneic sclera, but due to cultural, religious beliefs and other factors, the application of allogeneic sclera is relatively restricted; secondly, after reinforcement, due to the barrier effect of the material itself, according to the long-term Observation can cause macular ischemia in the eye and cause severe vision loss again. The development of the posterior scleral reinforcement system for high myopia solves the two limiting factors of posterior scleral reinforcement and will improve the treatment effect of pathological myopia.

Vesber system and flying inspection knowledge contest started~

In order to further improve the company’s quality management capabilities, improve employees’ understanding of the system and flying inspection, and deeply understand and comprehensively promote the construction of the quality management system, Satellite TV launched the system and flying inspection knowledge contest.

Contest links: written test questions, rush answer questions, mandatory answer questions, case analysis questions

Participating members: Quality Management Group, Technical Group, Production Group, Marketing Group, Logistics Group

Rewards: team awards, personal best performance awards (rewards greatly increased ~)

The details are as follows: 1. Team Award: The top three groups in the three rounds with the highest total score are the top three, which can be awarded separately. 2. Personal best performance award: The top three individuals with the highest individual scores in the three rounds are the top three, and they can be rewarded separately.

Written test questions-with confidence

At 4:30 on the 14th, the horn of the company’s quality system knowledge contest sounded! The competition first came to the first link-written test questions, the main assessment quality manual compilation and main content.

Answer questions-chase after victory

On the afternoon of the 15th, the second part of the Knowledge Contest was held—quick answers. The topics of this knowledge contest involve medical device regulations and system documents of various departments, and a variety of test questions test everyone’s ability to reserve and apply various knowledge. The atmosphere of the competition was warm, and the climax was repeated.

Mandatory questions-single-handedly

Then entered the personal must-answer questions, the players on the field answered calmly, the answers were fluent, showing a solid foundation for the quality management system.

Case study questions-team operations

The last link, the case analysis question, analyzes the case according to the guidelines for the on-site inspection of implantable medical devices for medical device production quality management standards.

After four rounds of intense competition, the final score is finally released! The technical department, quality control department and production department won the first, second and third places respectively!

At the same time, three people also won the personal best performance awards, and each received a generous bonus ✿✿ヽ(°▽°)ノ✿~

This knowledge contest has ended successfully, and the unsuccessful teams do not have to be discouraged. The company will continue to carry out knowledge contests in the second half of the year to encourage everyone to compete benignly. Grow and continue to innovate!










第一期 | Vesber 最佳RIO论文推荐

学习学习再学习,分享分享再分享!学习使人年轻,学习使人快乐。为给大家提供眼科最新资讯,卫视博将每个月从三大权威杂志:Retina、Investigative Ophthalmology & Visual Science、Ophthalmology中各推荐一篇眼科相关论文,合称“最佳RIO论文推荐”。接下来且看学习心得,且听论文分解▽

Retina · 推荐

《ADVERSE EVENTS OF THE ARGUS II RETINAL PROSTHESIS: Incidence, Causes, and Best Practices for Managing and Preventing Conjunctival Erosion》(Retina. 2020,40(2):303-311.)
《ARGUS II视网膜芯片的不良反应:结膜糜烂的发生率、原因和管理预防的最佳措施》
Purpose:To analyze and provide an overview of the incidence, management, and prevention of conjunctival erosion in Argus II clinical trial subjects and postapproval patients.
Methods:This retrospective analysis followed the results of 274 patients treated with the Argus II Retinal Prosthesis System between June 2007 and November 2017, including 30 subjects from the US and European clinical trials, and 244 patients in the postapproval phase. Results were gathered for incidence of a serious adverse event, incidence of conjunctival erosion, occurrence sites, rates of erosion, and erosion timing.
方法:回顾性分析了2007年6月至2017年11月间274例使用Argus II视网膜修复系统治疗的患者的结果,其中30例来自美国和欧洲临床试验,244例处于批准后阶段。收集严重不良事件发生率、结膜糜烂发生率、发生部位、糜烂率和糜烂时间的结果。
Results:Overall, 60% of subjects in the clinical trial subjects versus 83% of patients in the postapproval phase did not experience device- or surgery-related serious adverse events. In the postapproval phase, conjunctival erosion had an incidence rate of 6.2% over 5 years and 11 months. In 55% of conjunctival erosion cases, erosion occurred in the inferotemporal quadrant, 25% in the superotemporal quadrant, and 20% in both. Sixty percent of the erosion events occurred in the first 15 months after implantation, and 85% within the first 2.5 years.
Conclusion:Reducing occurrence of conjunctival erosion in patients with the Argus II Retinal Prosthesis requires identification and minimization of risk factors before and during implantation. Implementing inverted sutures at the implant tabs, use of graft material at these locations as well as Mersilene rather than nylon sutures, and accurate Tenon’s and conjunctiva closure are recommended for consideration in all patients.
结论:减少Argus II视网膜芯片患者结膜糜烂的发生需要在植入前和植入过程中识别并最小化危险因素。建议考虑对所有患者在植入片处实施倒转缝合,在这些位置使用和移植物材料一致的美西林线缝合,而不是尼龙线缝合,以及准确的将Tenon’s膜和结膜闭合。
推荐理由:创新产品总是充满困难和挑战,Argus 从I代到 II代,历经十余年的不断探索和改进,虽有一定的并发症,但是仍然给患者带来了光明和希望。这是一篇回顾性分析一种Argus II视网膜芯片在临床试验期及获批后使用情况的研究。入选了长达10年间的包括临床试验和获批后的274例患者数据,重点分析了Argus II视网膜芯片的术后结膜糜烂的发生率,部位与发生时间,及给出了一系列相关预防管理建议。

IOVS · 推荐

《Angiotensin-(1–7) Attenuates Protein O-GlcNAcylation in the Retina by EPAC/Rap1-Dependent Inhibition of O-GlcNAc Transferase》(Invest Ophthalmol Vis Sci. 2020;61(2):24.)
血管紧张素-(1-7)通过EPAC / Rap1依赖抑制O-乙酰氨基葡萄糖转移酶降低视网膜蛋白 O-乙酰氨基葡萄糖乙酰化的表达
Purpose:O-GlcNAcylation of cellular proteins contributes to the pathophysiology of diabetes and evidence supports a role for augmented O-GlcNAcylation in diabetic retinopathy. The aim of this study was to investigate the impact of the renin-angiotensin system on retinal protein O-GlcNAcylation.
目的: 细胞蛋白的O-乙酰氨基葡萄糖乙酰化有助于了解糖尿病的病理生理,证据支持在糖尿病性视网膜病变中O-乙酰氨基葡萄糖乙酰化的表达增加。这项研究的目的是研究肾素-血管紧张素系统对视网膜蛋白O-乙酰氨基葡萄糖乙酰化的影响。
Methods:Mice fed a high-fat diet were treated chronically with the angiotensinconverting enzyme inhibitor captopril or captopril plus the angiotensin-(1–7) Mas receptor antagonist A779. Western blotting and quantitative polymerase chain reaction were used to analyze retinal homogenates. Similar analyses were performed on lysates from human MIO-M1 retinal Müller cell cultures exposed to media supplemented with angiotensin-(1–7). Culture conditions were manipulated to influence the hexosamine biosynthetic pathway and/or signaling downstream of the Mas receptor.
方法: 饲喂高脂饮食的小鼠长期接受血管紧张素转换酶抑制剂卡托普利或卡托普利加血管紧张素-(1-7)Mas受体拮抗剂A779的治疗。蛋白质印迹和定量聚合酶链反应用于分析视网膜匀浆。对暴露于补充血管紧张素(1-7)-的培养基中的人MIO-M1视网膜Muller细胞裂解物进行了类似的分析。控制培养条件以影响己糖胺的生物合成途径和/或Mas受体下游的信号传导。
Results:In the retina of mice fed a high-fat diet, captopril attenuated protein O-GlcNAcylation in a manner dependent on Mas receptor activation. In MIO-M1 cells, angiotensin-(1–7) or adenylate cyclase activation were sufficient to enhance cyclic AMP (cAMP) levels and inhibit O-GlcNAcylation. The repressive effect of cAMP on OGlcNAcylation was dependent on exchange protein activated by cAMP (EPAC), but not protein kinase A, and was recapitulated by a constitutively active variant of the small GTPase Rap1. We provide evidence that cAMP and angiotensin-(1–7) act to suppress OGlcNAcylation by inhibition of O-GlcNAc transferase (OGT) activity. In cells exposed to an O-GlcNAcase inhibitor or hyperglycemic culture conditions, mitochondrial superoxide levels were elevated; however, angiotensin-(1–7) signaling prevented the effect.
结果:在高脂饮食的小鼠视网膜中,卡托普利以依赖Mas受体激活的方式减弱了蛋白O-乙酰氨基葡萄糖乙酰化。在MIO-M1细胞中,血管紧张素-(1-7)或腺苷酸环化酶激活足以增强环腺苷酸(cAMP)的水平并抑制O-乙酰氨基葡萄糖乙酰化。cAMP对O-乙酰氨基葡萄糖乙酰化的抑制作用取决于cAMP激活的交换蛋白(EPAC),而不取决于蛋白激酶A,并被短三磷酸鸟苷酶 Rap1的组成型活性变构体重构。我们提供的证据表明,cAMP和血管紧张素-(1-7)通过抑制O-乙酰氨基葡萄糖转移酶(OGT)的活性来抑制O-乙酰氨基葡萄糖乙酰化的作用。在暴露于O-乙酰氨基葡萄糖酶抑制剂或高血糖培养条件下的细胞中,线粒体过氧化物水平升高;然而,血管紧张素-(1-7)信号传导阻止了这种作用。
Conclusion:Angiotensin-(1–7) inhibits retinal protein O-GlcNAcylation via an EPAC/Rap1/OGT signaling axis.
结论: 血管紧张素-(1-7)通过EPAC / Rap1 / OGT信号通路抑制视网膜蛋白O-乙酰氨基葡萄糖乙酰化。
有研究表明,在晶状体,角膜,视网膜色素上皮,神经视网膜和视网膜脉管系统中已经发现了O-乙酰氨基葡萄糖乙酰化蛋白的表达。在这项研究中,作者发现在高脂饮食小鼠的视网膜中,卡托普利减弱了视网膜蛋白 O-乙酰氨基葡萄糖乙酰化,并且通过Mas受体抑制作用阻止了该作用。这一发现提供了新的见解,探讨了Ang1–7水平升高在视网膜抑制ACE的有益作用中的作用。同时,在本研究中,作者认为线粒体功能障碍和ROS产生增加是糖尿病性视网膜病发展的关键。所以,这篇文章提示了我们对于一些糖尿病病或者糖尿病视网膜病变的患者,服用血管紧张素酶抑制剂,可能会有利于患者减缓疾病的发生,减轻患者的痛苦。但本文属于临床前基础研究,尽管在研究中确定了Ang1-7,蛋白O-乙酰氨基葡萄糖乙酰化和视网膜中ROS产生之间的新型分子联系,但其中有部分的机制研究仍不是特别清晰;同时,本研究只进行了动物实验,是否真的可以应用到人身上仍是一个疑问。因此我们需要更多的研究来证明Ang1-7对于治疗糖尿病视网膜病变的作用。
附录:Ang1-7 抑制视网膜蛋白O-乙酰氨基葡萄糖乙酰化的工作模型

Ophthalmology · 推荐

《A Collaborative Retrospective Study on the Efficacy and Safety of Intravitreal Dexamethasone Implant (Ozurdex) in Patients with Diabetic Macular Edema: The European DME Registry Study》(Ophthalmology. 2020;127(3):377-393.)
Purpose:To evaluate the efficacy, effect profile, and safety of dexamethasone implant on diabetic macular edema (DME) in a real-life setting, further comparing results by DME duration, previous treatment status, and diabetic control.
Methods:Data were analyzed in 2 perspectives: per injection, in which all measurements were grouped and baseline was defined as the day of injection, and thus the pharmacodynamics of single injections could be assessed; and injection series, defined as 2 or more injections with 3 to 6 months between injections analyzing the outcome 3 to 6 months after the last injection.
Results:Overall, 762 injections were administered to 340 eyes of 287 patients. Injection series analysis included 171 series in 171 eyes of 150 patients, for a total of 444 injections, with a mean follow-up of 1.7±0.8 years. Of the 762 injections analyzed per injection, 22.7% achieved a 15-letter or more improvement, and 37.8% achieved a 10-letter or more improvement. Mean time to peak improvement was 81.9±39.7 days. Mean maximum change in central macular thickness (CMT) was –174±171 μm. Overall, 7.6% lost 15 or more letters. More eyes with early DME gained 10 or more letters and fewer eyes lost 10 or more letters compared with eyes with late DME (47.4% vs. 33.9% [P = 0.001] and 8.2% vs. 13.5% [P = 0.029], respectively). Patients with controlled diabetes showed greater CMT reduction (P = 0.0002). A higher percentage of treatment-naive patients gained 10 or 15 letter or more in BCVA (P = 0.001 and P = 0.006, respectively). Intraocular pressure elevation of more than 25 mmHg was found following 7.9% of injections; no endophthalmitis was reported.
结果:总体上,对287例患者的340眼进行了762次注射。注射系列分析包括150例患者的171只眼的171个系列,共444次注射,平均随访时间为1.7±0.8年。在762次注射的每次分析中,22.7%的提高了15个字母或以上,37.8%的提高了10个字母或以上。达到提高的峰值的平均时间为81.9±39.7天。黄斑区中心凹厚度(CMT)的平均最大变化为–174±171μm。总体而言,7.6%的患者降低了15个或以上的字母。与晚期DME相比,早期DME中更多的眼睛提高10个或以上的字母,较少的眼睛降低10个或以上字母(分别为47.4%对33.9%[P = 0.001]和8.2%对13.5%[P = 0.029] )。控制的糖尿病患者的CMT减小更明显(P = 0.0002)。未接受治疗的患者中,BCVA获得10或15个字母或更多的比例更高(分别为P = 0.001和P = 0.006)。7.9%的注射后眼内压升高超过25 mmHg;没有眼内炎的报道。
Conclusion:Dexamethasone implant is an effective and safe treatment for DME. Peak improvement was achieved 3 months after injection and dissipated thereafter. Clinicians and providers may consider shortening treatment intervals.

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一场新冠疫情席卷全球,中国凭借强有力的措施阻止了病毒的继续蔓延,同时让全世界看到了中国先进的医疗技术。经过数十年的飞速发展,中国创造已开始领先全球,其中医疗器械折叠式人工玻璃体球囊(FCVB)就是中国创造的典型代表。FCVB是由广州卫视博生物科技有限公司研发生产的高端眼科医疗器械,不仅在国内治愈了一千多名严重眼外伤和硅油依赖眼患者,同时走出国门,为英国、希腊、荷兰、比利时、波兰、俄罗斯和土耳其等国家带去先进眼科产品,为全球患者带来希望。这次,FCVB还横跨到另一个半球——南半球,远征澳大利亚。作为一款全球首创的眼科产品,FCVB的国际影响力持续提升。早在去年10月份,来自澳大利亚的Dr. Qureshi就对FCVB表示赞赏,他当时就曾和产品的研发人高前应教授表示,遇到合适的病人将会使用这款产品。

将近半年后,Dr. Qureshi终于决定开展FCVB手术。在术前的几周,他与卫视博进行了详细的沟通和培训,对FCVB的折叠、植入等有了充分的认识。在3月19日开展了首例手术。值得一提的是,这次手术采用了远程视频跟台。该名患者James是一名硅油眼,并且患有高度远视,曾植入了人工晶体。但是随着眼球逐渐萎缩,他无法接受日渐变小的眼睛,就来到医院咨询。Dr. Qureshi结合国际眼外伤评分表判断他适合做FCVB。19日中午开始手术,虽然这是Dr. Qureshi的首次手术,但是在术前的充分培训下,并且高教授在屏幕前密切跟进给予协助,紧张的2小时后终于顺利为James植入了FCVB。
虽然第一台手术获得了成功,但是Dr. Qureshi团队和高教授仍不敢松懈,因为接下来还将进行第二台手术。第二名患者Nikhil也是硅油依赖眼。有了一例的植入经验,Dr. Qureshi和高教授配合也越来越默契,这让第二台手术也很顺利。即使在植入中出现了FCVB位置不正的问题,但是在双方配合和努力下,最终也摆正了FCVB。术后Dr. Qureshi表示,手术效果比预期还要顺利和成功。一周后Dr. Qureshi反馈,术后两位患者虽有短暂眼压高的情况,但是现已恢复稳定,状况良好。




调研过程中,高总经理向副区长一行详细介绍了公司发展历史和公司代表产品折叠式人工玻璃体球囊(Foldable Capsular Vitreous Body, 简称 FCVB)的研发生产和临床应用等情况。高总经理提到,FCVB采用进口高分子材料,由球囊、引流管和引流阀组成,可以精确模拟人眼玻璃体结构,通过引流阀注入介质(硅油),恢复玻璃体支撑视网膜和眼球的功能, 治疗严重眼外伤和硅油依赖眼。副区长一行认真听取了高总经理对产品和技术的介绍,对FCVB眼科新技术表示高度赞赏。