July | Vesber’s Best RIO Paper Recommendation

R —— Retina Recommendation
Purpose:To identify factors associated with persistent subretinal fluid (SRF) after small-gauge pars plana vitrectomy for primary rhegmatogenous retinal detachment.
Methods:This retrospective study included patients from 2 tertiary centers who
underwent pars plana vitrectomy for repair of rhegmatogenous retinal detachment between2013 and 2016. Preoperative and intraoperative parameters were examined for associationwith development of SRF.
Results:Overall, 153 eyes of 153 patients, mean age of 55.2 ± 17.9 years were included. Persistent SRF occurred in 15.0% (n = 23) and was associated with high myopia (65.22 vs. 26.15%, P , 0.001), macula-involving retinal detachment (91.30 vs. 66.15%, P = 0.02), phakic lens status (86.96 vs. 66.15%, P = 0.04), and younger age (47.8 ± 18.7 vs. 56.5 ± 17.5, P = 0.04) while drainage retinotomy was protective (13.04 vs. 34.11%, P = 0.04). In multivariate analysis, high myopia (P = 0.009) and macula-involving retinal detachment (P = 0.004) were associated with SRF, while drainage retinotomy was protective (P = 0.03). Persistent SRF was associated with outer retinal band irregularity (30.4 vs. 9.3%, P = 0.005). There were no significant differences in terms of change in best-corrected visual acuity from presentation (P = 0.70), or final best-corrected visual acuity (P = 0.54).
Conclusion:Eyes with preoperative high myopia and macular involvement, and those inwhich a drainage retinotomy was not performed, were more likely to develop persistent SRF.
Recommended reason:
This article discusses factors related to determining persistent subretinal fluid (SRF) in patients with primary rhegmatogenous retinal detachment treated with minimally invasive vitrectomy. The results showed that persistent SRF was associated with high myopia. In multivariate analysis, high myopia and retinal detachment involving the macula were associated with SRF. The special feature of the article is that the author innovatively refers to a number of different ophthalmological diseases, compares the correlation between different diseases and SFR, and uses mathematical statistics to obtain preoperative high myopia and macular involvement eyes and undrained retina Incision eye is closely related to SFR, that is, high myopia, lens state and low age are not related. This article has certain limitations. On the one hand, the main age of the sample sampling is 55.2±17.9 years old, and there is no control in the low-age group; on the other hand, the study time is only three years from 2013 to 2016, which requires longer observation time and frequency data to support. In addition, the influence of variables in this article on the condition of the contralateral eye was not included in the study.
I —— Investigative Ophthalmology & Visual Science Recommendation
Increased Glial Fibrillary Acid Protein and Vimentin in Vitreous Fluid as a Biomarker for Proliferative Vitreoretinopathy
Purpose:Glial fibrillary acid protein (GFAP) and vimentin are type III intermediate filament proteins, ubiquitously expressed in retinal glial cells. Under retinal stress, both GFAP and vimentin are well-known sensitive markers for retinal gliosis. However, little is known about whether these proteins are released into the vitreous body in response to retinal gliosis or are related to the severity of retinal gliosis seen in proliferative vitreoretinopathy (PVR).
Methods:Vitreous fluids were collected from 44 patients who underwent pars plana vitrectomy for macular hole (Group 1; n = 8), epiretinal membrane (Group 2; n = 8), or retinal detachment (RD) with various degrees of PVR (Group 3; n = 28). The severity of PVR was determined by cumulative scores using PVR classification. GFAP, vimentin, and total protein levels from the vitreous samples were measured.
Results:Both GFAP and vimentin levels were significantly elevated in vitreous fluid from Group 3 (RD) compared with Groups 1 and 2 (P < 0.01). GFAP levels (ng/mL) were 12.4± 9.8, 17.5 ± 17.7, and 572.0 ± 11659.7, and vimentin levels (ng/mL) were 40.8 ± 61.9, 88.6 ± 86.8, and 3952.8 ± 8179.5 in Groups 1, 2, and 3, respectively. Total protein levels were not significantly different among the three groups. Elevated GFAP and vimentin levels in Group 3 were positively correlated with the areas of RD (P < 0.01, r = 0.53 in GFAP and P < 0.05, r = 0.46 in vimentin) and PVR scores (P < 0.05, r = 0.46 in GFAP and P < 0.00001, r = 0.76 in vimentin).
Conclusion:Our data suggest that human vitreous GFAP and vimentin are protein biomarkers for PVR, and reactive gliosis may play a part in PVR formation.
Recommended reason:
In this study, the macular hole (group 1), macular epiretinal membrane (group 2), and retinal detachment (RD) with different degrees of PVR (group 3) were compared in three groups of patients receiving PPV in vitreous fibrillary acidic protein (group 3). GFAP), vimentin and total protein levels, and the relationship between the three protein levels and RD area and PVR score. The results showed that there was no significant difference in total protein levels among the three groups. The levels of GFAP and vimentin in group 3 were significantly higher than those in the other two groups, and they were positively correlated with RD area and PVR score. This study is the first to prove that the increase in vitreous GFAP and vimentin is related to the severity of PVR. In the absence of treatment for PVR, early identification and prevention of PVR formation are important to prevent further vision loss. The study showed that the increased levels of GFAP and vimentin in the vitreous after RD may be a sign of the formation of PVR, and patients in this case need more active treatment and prevention. The limitation of this study is that the number of patients is small, and the vitreous GFAP and vimentin lack normal physiological value. The cross-sectional design of the eye restricts researchers to further analyze the source of these proteins or the causal relationship between these proteins in retinal detachment and PVR. The role of GFAP and vimentin in the formation of PVR needs to be further studied in the future.
O —— Ophthalmology Recommendation
Myopia and Childhood Migration:A Study of 607 862 Adolescents
Purpose:Immigration studies can shed light on myopia development and reveal high-risk populations. To this end, we investigated the association among immigration, age at immigration, and myopia occurrence during adolescence.
Design:Population-based, retrospective, cross-sectional study.
Participants:Six hundred seven thousand eight hundred sixty-two adolescents, Israeli born and immigrants, with origins in the former Union of Soviet Socialist Republics (USSR), Ethiopia, or Israel, assessed for medical fifitness for mandatory military service at 17 years of age between 1993 and 2016.
Methods:Myopia and high myopia were defined based on right eye refractive data. Age at immigration was categorized into 0 to 5 years of age, 6 to 11 years of age, and 12 to 19 years of age. Univariate and multivariate logistic regression models were created. Myopia odds ratios (ORs) were calculated according to immigration status, with Israeli-born natives as controls. Next, myopia ORs were calculated according to age at immigration, with Israeli-born of same origin as controls. Main Outcome Measures: Myopia prevalence and ORs.
Results:Myopia was less prevalent among immigrants than Israeli-born controls. When stratifified according to age at immigration, a decrease in myopia prevalence and ORs with increasing age at migration were observed, most prominent in immigrants arriving after 11 years of age, who also showed lower high-myopia ORs. The immigrants from the USSR and Ethiopia arriving after 11 years of age showed a myopia OR of 0.65 (95% con- fifidence interval [CI], 0.63e0.67; P < 10e205) and 0.52 (95% CI, 0.46e0.58; P < 10e27) compared with the Israeliborn controls. Notably, Ethiopians arriving earlier than 5 years of age showed a 2-fold higher myopia OR than those migrating after 11 years of age.
Conclusion:Immigrants arriving after 11 years of age showed markedly lower ORs for myopia and high myopia relative to Israeli-born controls or those arriving during early childhood, likely because of environmental and lifestyle changes. Differences between immigrants arriving up to 5 years of age and those arriving between 6 and 11 years of age were relatively smaller, suggesting exposures at elementary school age play a greater role in this population.
Recommended reason:
Adolescents’ vision health is related to the future of the motherland. Under the background of the contemporary computer age, understanding the factors of adolescents’ myopia is very important to protect their vision. Based on the selection of a large number of 17-year-old young people’s physical examination data, the article compares the incidence of myopia among young people and the age of immigration. It is concluded that the incidence of myopia is relatively low among the children of native Israel, while the incidence of myopia is relatively low for children who are immigrants after the age of 11. It implies that the relative exposure factors of the local primary school age in Israel are related to the increase of myopia rate. The article adopts sufficient sample size and reliable data. Through the establishment of multiple comparisons, it is determined that the indirect impact of changes in the living environment on vision is unquestionable, suggesting that we are concerned about the impact of environmental changes on young people, especially the continuous changes in the multimedia age, even if we are in the same environment, we must also pay attention The environment of many years ago and the contemporary environment have an impact on the vision of young people. The limitation of the article is that the article only has eye diopter data and immigration age data, and there is no design for related environmental factors, educational factors, and social factors. In the future, further cause analysis can be considered for this point.
The original texts of the three papers have been placed on the Baidu network disk, click on the “link”, enter the extraction code: bp9j, you can download the paper.